Genetically Engineered Mouse Models Predict Cancer Drug Responsiveness in Human Tumors

Ultrasound imaging of mouse tumor showing response to chemotherapy. The mouse model allowed researchers to derive a new biomarker of chemotherapy responsiveness.

It’s a GEMM of a system. Genetically engineered mouse models that is. Using them allows scientists to study cancer in a way that more naturally mimics how human tumors exist within the complex environment of the body. UNC scientists used GEMMs to develop biomarkers for challenging molecular subtypes of human [...]

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Researchers Pinpoint Sources of Fibrosis-Promoting Cells That Ravage Organs

Raghu Kalluri, Ph.D., M.D.

Scientists have tracked down and quantified the diverse origins of cells that drive fibrosis, the incurable, runaway wound-healing that scars and ultimately destroys organs such as the lungs, liver and kidneys. Findings from research conducted at Beth Israel Deaconess Medical Center, Harvard Medical School and Massachusetts Institute of Technology in [...]

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Scientists Turn Muscular Dystrophy Defect On and Off in Cells

Matthew Disney, PhD, is an associate professor at The Scripps Research Institute.

For the first time, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified small molecules that allow for complete control over a genetic defect responsible for the most common adult onset form of muscular dystrophy. These small molecules will enable scientists to investigate potential new therapies [...]

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